SUGARNSALT Project
The Sodium Glucose Co-Transport-2 Inhibition Diabetes and Kidney Function Loss in Type 1 Diabetes (SUGARNSALT) research project
The Sodium Glucose Co-Transport-2 Inhibition Diabetes and Kidney Function Loss in Type 1 Diabetes (SUGARNSALT) is one of eight major research projects funded in the Canadian Institutes of Health Research (CIHR) ground-breaking initiative 100 Years of Insulin: Accelerating Canadian Discoveries to Defeat Diabetes, in the competition Team Grant: Diabetes Mechanisms and Translational Solutions. This project has recently received additional international funding from JDRF, read more in Project Updates below.
Purpose of the Study
The SUGARNSALT research project will study the effect of sodium glucose co-transport-2 (SGLT2) inhibitors for the prevention of kidney failure in people with type 1 diabetes. Diabetes is the leading cause of kidney failure amongst Canadians, and it is estimated that 11 million of them are currently living with some form of diabetic disease. Current therapies include SGLT2 inhibitors which have been observed to have a high effectiveness rate in delaying and/or preventing the need for dialysis in patients with type 2 diabetes. Unfortunately, very little experimental data is available to help individuals with type 1 diabetes. This is where the SUGARNSALT investigations will place their focus.
In sum, the research project will include:
A pilot study composed of a series of clinical trials that will test the risks and benefits of introducing SGLT2 inhibitors in treatment therapies for people with type 1 diabetes over a two-year period. Concurrently, a patient preference study will evaluate how patients judge the benefits versus risks of their treatment.
An analysis of Danish health records to assess the changes in the risk of kidney disease in Danish patients with type 1 diabetes who were also treated with SGLT2 inhibitors.
A mathematical model based on real-world data that will evaluate the treatment benefits of SGLT2 inhibitors in terms of their ability to decrease the risk of kidney failure, the need for dialysis or transplant, and the risk of heart failure.
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"There is a huge unmet need for people with type 1 diabetes. These patients have roughly a decade shorter lifespan and their risk of developing kidney disease during their lifetime is something in the order of 30 to 40%. Yet, the treatment regimen we provide today is the same as it has been for well over 20 years: insulin and control of blood pressure. None of the innovations available to those with type 2 diabetes have been approved for patients with type 1 diabetes."
Dr. David Cherney, SUGARNSALT Principal Investigator
Project Investigators
The SUGARNSALT project involves multiple investigators from various fields and dispersed throughout the country, some of which are previous members of our KRESCENT program.
Dr. David Cherney – SUGARNSALT Principal Investigator, University Health Network
Dr. David J.T. Campbell – SUGARNSALT Co-Principal Investigator, University of Calgary
Dr. Anita Layton – SUGARNSALT Co-Principal Investigator, University of Waterloo
Dr. Bruch Perkins – Co-Principal Investigator, Lunenfeld-Tanenbaum Research Institute
Dr. Sean Barbour – SUGARNSALT Co-Investigator, University of British Columbia
Dr. Tony Lam – SUGARNSALT Co-Investigator, University Health Network (Toronto)
Dr. Adeera Levin – SUGARNSALT Co-Investigator, University of British Columbia
Dr. Erik Lovblom – SUGARNSALT Co-Investigator, Sinai Health System
Dr. Istvan Mucsi – SUGARNSALT Co-Investigator, University of Toronto
Dr. Rémi Rabasa-Lhoret – SUGARNSALT Co-Investigator, CIRANO Group, University of Montreal
Dr. Valeria Rac – SUGARNSALT Co-Investigator, Toronto General Research Institute
Dr. Mehrshad Sadria – SUGARNSALT Co-Investigator, University of Waterloo
Dr. Peter Alexander Senior – SUGARNSALT Co-Investigator, University of Alberta
Dr. Ronald Sigal – SUGARNSALT Co-Investigator, Foothills Medical Centre
Dr. Vikas Srinivasan Sridhar – SUGARNSALT Co-Investigator, University Health Network
Dr. Aleksandra Vukobradovic – SUGARNSALT Co-Investigator, Toronto General Research Institute
Project Updates
Funding and Partners
The Kidney Foundation is committed to supporting the SUGARNSALT research project by raising $1 million in funding over five years with its End Diabetic Kidney Disease campaign. This investment will be matched by the Canadian Institutes of Health Research (CIHR).
We are thankful to the many partners who have also decided to join us in this mission and invest in its goal, including:
Astra Zeneca
The Maker Family (Bobby, Vinny, Karanpaul and Charanpaul)
Bayer
Find out more and support this work by visiting our End Diabetic Kidney Disease campaign page.


