Development of SHP2 inhibitors as a treatment for Acute kidney injury
General Audience Summary
Acute kidney injury is a sudden incident of kidney damage, which can also affect other organs such as the brain, heart, and lungs. The mortality rates associated with AKI are still high, therefore, the goal of identifying novel therapeutic targets and modalities to prevent and treat AKI is critically needed. Our proposal will focus on contributing to this goal by blocking the activity of one of the recently identified hallmarks in Acute kidney injury. Our team recently identified tools that have been shown to interact very strongly with this target and the objective of our proposal is to validate this approach as a possible treatment for Acute kidney injury. Findings from our proposal will advance the development of a new generation of promising and new treatments to prevent Acute kidney injury.
