PHOSPHATE-DIET: Evaluation of dietary phosphorus intake within a randomized trial
Co-Applicant(s): Ivana Prce, Kelly Picard, Michael Walsh, Ron Wald
Lay Abstract
Most people with kidney disease will be taught to reduce the amount of phosphorus in their diets. This is an important part of dealing with a condition hyperphosphatemia, which means there's too much phosphorus in the blood. However, what we don’t know is what level of phosphorus in the blood is right for adults on dialysis. We also worry that by teaching patients to lower the amount of phosphorus in their diet, we are making it harder for them to eat healthy foods. Many healthy foods, such as nuts, seeds, beans and whole grains are high in phosphorus. That’s why we are doing a study called the PHOSPHATE-DIET trial, where some patients will be given extra supports (through diet education and medications) to help lower the amount of phosphorus in their blood. We want to see how this advice affects what happens to people’s health and how it changes how they eat. We will do this by asking a group of new patients in the study to tell us what they've been eating two times during the study. The main goal of this study is to figure out how aiming for a lower amount of phosphorus in the blood, compared to a higher amount, affects what people eat and how this impacts their health. This will give us good evidence about the connection between phosphorus levels and diet and helps us give better advice about phosphorus in the diet for adults on dialysis.
