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Patient centered outcomes in childhood onset nephrotic syndrome

Lay Summary Nephrotic syndrome is the most common childhood kidney disease in the world. The rates of nephrotic syndrome have doubled over the past ten years in Ontario, where 5 children per 100,000 children are affected. South Asian children are affected by nephrotic synd...

Primary care physician involvement and quality of care for patients on dialysis

Lay Summary Background: Patients on dialysis have high healthcare needs that go beyond their regular dialysis treatments. Therefore, their care also includes preventative health, symptom management, mental health, and acute illness. Given patients’ frequent presence in the...

Fluid removal strategies on renal replacement therapy

Lay Summary Individuals who becomes critically ill and are admitted to the intensive care unit often develop kidney injury which can be severe enough to impair the ability to produce urine. In this setting, fluid is likely to accumulate and this may cause important complica...

Potential roles of antibodies in the pathogenesis of nephrotic syndrome

Lay Summary Nephrotic syndrome (NS) is a common form of kidney disease that happens when the kidney leaks a massive quantity of protein in the urine. This continuous loss of protein creates body swelling and is toxic to the kidney. Untreated, it leads to chronic kidney dise...

The Impact of Subclinical Primary Aldosteronism on Kidney Disease

General Audience Summary Background: Hypertension (high blood pressure) management generally involves a ‘one size fits all’ approach. Employing a more personalized approach targeting the specific cause of an individual patient’s hypertension provides the opportunity to impr...

Examining the Impact of the COVID-19 Pandemic on Chronic Kidney Disease Patients, their Family Careg

Lay Abstract The COVID-19 pandemic has been a very difficult process and experience for so many. It has been especially tough for people with kidney disease, their families and support systems, and for health care providers. Unfortunately, we don’t know too much about how t...

Predicting Individual Risk of Peripheral Arterial Disease and Its Complications in Hemodialysis: Eva

Lay Abstract Peripheral arterial disease (PAD) is a progressive condition in which narrowed or blocked blood vessels result in reduced blood flow to the legs. PAD results in impaired mobility, low quality of life, and other serious complications, such as foot ulceration and...

Better Decisions for Better Outcomes from Deceased Donor Kidneys

Lay Abstract Kidney transplant is the treatment of choice for patients with kidney failure. Kidneys may come from living or deceased donors. After a potential suitable deceased donor kidney is identified, the kidney is matched to potential recipient candidates in a process ...

Risk and trend in the burden of stroke among patients on chronic maintenance dialysis

Supervisor(s): Aminu Bello Lay Summary Background : Patients with kidney failure undergoing chronic maintenance dialysis have a higher risk of cardiovascular diseases compared to the general population. The heightened risk of cardiovascular disease in these populations is...

Drug Repurposing for treatment of Alport Syndrome

Co-Applicant(s):  James Scholey Lay Abstract Drug-repurposing for treatment of Alport Syndrome Alport syndrome (AS) is a rare inherited kidney disease caused by mutations in one of three collagen genes named COL4A3, COL4A4, or COL4A5 and is associated with premature kid...

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