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Risk of acute kidney injury in patients randomized to a restrictive versus liberal approach to red-b

Lay Summary When people have heart surgery their kidneys can sometimes be injured. This is known as “acute kidney injury”. This condition is very serious and sometimes causes kidney failure or death. To diagnose acute kidney injury, blood tests are needed before and after ...

Determining the influence of processes, structure and inter-professional relational networks within

Lay Summary Background: To optimize organ donation and transplantation the nature and impact of complex organizational characteristics, such as inter-professional roles and relationships, and hospital organizational structure processes, need to be understood. We know that ...

p-Cresol and mycophenolate interaction in adult kidney transplant patients

General Audience Summary Summary: Mycophenolate (or mycophenolic acid) is a commonly used medication for life-long maintenance to prevent the body from rejecting the transplanted kidney. Mycophenolate is usually prescribed in a fixed regimen, and almost all patients would ...

The efficacy, mechanisms and safety of SGLT2i and GLP1RA combination therapy in kidney transplant re

Lay Abstract Kidney transplant recipients (KTR) are at high risk of death from heart disease after transplantation, as well as graft failure, where the kidney transplant no longer works and dialysis or another kidney transplant is required.  New types of drugs called sodi...

Flu Season is Coming - Don’t Forget to Get Your Shots!

Beyond the changing colours and prospect of flakes of snow, the cooler temperatures also mark the start of cold and flu season. People living with kidney disease are at higher risk from severe illness from both the flu and COVID-19, so it's crucial to take precautions. You ma...

Jason's Story

Laying in a hospital bed for three weeks does a lot to a person. Especially to a man who doesn’t believe he belongs there. I had lost a lot of weight. I was exercising regularly and eating well. I didn’t smoke or drink. I had made travel promises to my wife and kids. Getting...

Understanding the pathophysiology of uremic symptoms: a pilot mechanistic study of dialysate cooling

An alarming 24,000 Canadians (and over two million people worldwide) suffer from serious kidney failure and rely on a dialysis machine to clean their blood. Dialysis poses significant challenges; one in three patients die within a year of starting dialysis and those who underg...

Long-term kidney and heart outcomes after acute kidney injury among newborns and children

Lay Summary Acute kidney injury (AKI) is sudden damage to the kidneys that causes them to not work properly. It occurs in one in five and one in three hospitalized adults and children, respectively. If the kidneys shut down completely, this may require temporary support in...

Effect of an exercise rehabilitation program on symptom burden in hemodialysis: a randomized control

Lay Summary People with kidney failure who require hemodialysis to sustain life have multiple symptoms, such as fatigue, pain, and difficulty sleeping which are difficult to treat. This affects their ability to perform everyday activities, enjoy life, and likely increases ...

Modelling Alport syndrome using iPSC-derived glomeruli

Lay Summary One of the main roles of the kidney is to filter the blood, removing waste products and toxins. The units responsible for this filtration are called glomeruli, inside which two specialized cell types, the podocytes and the endothelial cells, create a barrier se...

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