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Long-term kidney and heart outcomes after acute kidney injury among newborns and children

Lay Summary Acute kidney injury (AKI) is sudden damage to the kidneys that causes them to not work properly. It occurs in one in five and one in three hospitalized adults and children, respectively. If the kidneys shut down completely, this may require temporary support in...

Patient centered outcomes in childhood onset nephrotic syndrome

Lay Summary Nephrotic syndrome is the most common childhood kidney disease in the world. The rates of nephrotic syndrome have doubled over the past ten years in Ontario, where 5 children per 100,000 children are affected. South Asian children are affected by nephrotic synd...

Modelling Alport syndrome using iPSC-derived glomeruli

Lay Summary One of the main roles of the kidney is to filter the blood, removing waste products and toxins. The units responsible for this filtration are called glomeruli, inside which two specialized cell types, the podocytes and the endothelial cells, create a barrier se...

Preventing Kidney Disease by Preventing Protein Misfolding

Lay Summary Acute kidney injury (AKI) is sudden damage to the kidneys that causes them to not work properly. It occurs in one in five and one in three hospitalized adults and children, respectively. If the kidneys shut down completely, this may require temporary support in...

The Impact of Subclinical Primary Aldosteronism on Kidney Disease

General Audience Summary Background: Hypertension (high blood pressure) management generally involves a ‘one size fits all’ approach. Employing a more personalized approach targeting the specific cause of an individual patient’s hypertension provides the opportunity to impr...

p-Cresol and mycophenolate interaction in adult kidney transplant patients

General Audience Summary Summary: Mycophenolate (or mycophenolic acid) is a commonly used medication for life-long maintenance to prevent the body from rejecting the transplanted kidney. Mycophenolate is usually prescribed in a fixed regimen, and almost all patients would ...

Fluid removal strategies on renal replacement therapy

Lay Summary Individuals who becomes critically ill and are admitted to the intensive care unit often develop kidney injury which can be severe enough to impair the ability to produce urine. In this setting, fluid is likely to accumulate and this may cause important complica...

Examining the Impact of the COVID-19 Pandemic on Chronic Kidney Disease Patients, their Family Careg

Lay Abstract The COVID-19 pandemic has been a very difficult process and experience for so many. It has been especially tough for people with kidney disease, their families and support systems, and for health care providers. Unfortunately, we don’t know too much about how t...

Better Decisions for Better Outcomes from Deceased Donor Kidneys

Lay Abstract Kidney transplant is the treatment of choice for patients with kidney failure. Kidneys may come from living or deceased donors. After a potential suitable deceased donor kidney is identified, the kidney is matched to potential recipient candidates in a process ...

Predicting Individual Risk of Peripheral Arterial Disease and Its Complications in Hemodialysis: Eva

Lay Abstract Peripheral arterial disease (PAD) is a progressive condition in which narrowed or blocked blood vessels result in reduced blood flow to the legs. PAD results in impaired mobility, low quality of life, and other serious complications, such as foot ulceration and...

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