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Lay Summary
During surgery, a patient’s blood pressure can sometimes drop very low. This can starve the body’s vital organs of blood and oxygen. POISE-3, a randomized controlled trial, is testing a new strategy to keep the blood pressure from falling too low during surgery. POISE-3 started in June 2018 and will determine if patients who receive the new strategy have fewer heart attacks than those who receive a usual-care strategy.
 
Dr. Garg want to conduct a substudy of POISE-3 to see if this strategy can also protect the kidneys during surgery. This is an important question: each year, 20 million patients who have surgery have their kidneys injured and 20,000 develop kidney failure. Researchers are trying to find better ways to protect the kidneys during surgery.
 
To conduct this substudy, additional kidney measurements are needed in the POISE-3 trial. The
leaders of the POISE-3 trial have agreed to add these measurements.  At the end of the trial, the team will determine if the risk of acute kidney injury is lower in patients who receive the new strategy compared to patients in the control group who receive a usual-care strategy. By adding kidney measurements to this large trial, the team can efficiently examine whether a new strategy to avoid low blood pressure during surgery protects the kidneys. They will also determine if this strategy works well in patients who have kidney disease before surgery.