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Molecular Mechanism(s) of Intrarenal RAS Regulation of Sodium-Glucose Co-Transporter 2 (Sglt2) Expre

Lay Abstract Kidney Renin-Angiotensin System (RAS) and Sodium-Glucose Co-transporter 2 (SGLT2) in Diabetes Persistent hypertension and diabetes are two major risk factors for the development and progression of end-stage kidney disease (ESKD), accounting for 75% of all ESKD ...

SGLT2 inhibition: impact on mitochondrial mice PT

Lay Abstract Role of proximal tubule (PT) sodium-glucose cotransporters (SGLT2) in DKD: The renal complications of diabetes include glomerular, vascular, and tubulo-interstitial processes characterized by an initial hyperfiltration, hypertrophy of the glomerulus and proxim...

Why Kidneys are so Important

Kidneys regulate water For your body to work properly, it must contain just the right amount of water. One of the important jobs of the kidneys is to remove excess water from the body or to retain water when the body needs more. Kidneys help to balance the body's minerals ...

SUGARNSALT Project

The Sodium Glucose Co-Transport-2 Inhibition Diabetes and Kidney Function Loss in Type 1 Diabetes (SUGARNSALT) research project The Sodium Glucose Co-Transport-2 Inhibition Diabetes and Kidney Function Loss in Type 1 Diabetes (SUGARNSALT) is one of eight major research pro...

Stop Marketing to Kids

Restricting Marketing of Unhealthy Foods and Beverages to Children and Youth in Canada Obesity levels among children in Canada are at historically high levels. 1 Obesity has been linked to the development of chronic diseases, including kidney disease, with overweight and ob...

Oxidative Stress and Regulation of SGLT2 Expression in Diabetic Kidney

General Audience Summary 90% of glucose filtered by the kidney is reabsorbed in renal proximal tubules (RPTs) by a protein called sodium-glucose cotransporter 2 (SGLT2). Since SGLT2 expression is upregulated and SGLT2-mediated glucose reabsorption is increased in the diabet...

Molecular mechanisms mediating paracellular intestinal Pi absorption and the development of CVD

The most common cause of death in persons with kidney failure is cardiovascular disease. In persons with chronic kidney disease and end-stage renal disease, blood phosphate levels directly correlate with cardiovascular diseases including heart attack and stroke. This is becaus...

The role of prostaglandin E2 and their receptor subtypes on kidney disease

Lay Summary Hypertension and diabetes are leading causes of chronic kidney disease and both have reached epidemic status worldwide. Despite the many efforts aimed at understanding the pathogenesis of hypertensive kidney disease, to this day the therapeutic approaches are i...

Your Diet On Dialysis

Most people who are on dialysis need to make some changes to the way they eat.  Choosing the right foods when you’re on dialysis is very important to your health and well-being, and it can sometimes be challenging.  There is no standard kidney diet; eating right on dialysis wi...

Nutrition in Chronic Kidney disease patients

Lay summary Do you eat bananas? Stop! Eat doughnuts instead. Sounds crazy doesn’t it? Well, if you are living with kidney disease, your health care provider may inadvertently be sending you this message. That is because people with kidney disease often need low potassium die...

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