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Molecular Mechanism(s) of Intrarenal RAS Regulation of Sodium-Glucose Co-Transporter 2 (Sglt2) Expre

Lay Abstract Kidney Renin-Angiotensin System (RAS) and Sodium-Glucose Co-transporter 2 (SGLT2) in Diabetes Persistent hypertension and diabetes are two major risk factors for the development and progression of end-stage kidney disease (ESKD), accounting for 75% of all ESKD ...

SGLT2 inhibition: impact on mitochondrial mice PT

Lay Abstract Role of proximal tubule (PT) sodium-glucose cotransporters (SGLT2) in DKD: The renal complications of diabetes include glomerular, vascular, and tubulo-interstitial processes characterized by an initial hyperfiltration, hypertrophy of the glomerulus and proxim...

Oxidative Stress and Regulation of SGLT2 Expression in Diabetic Kidney

General Audience Summary 90% of glucose filtered by the kidney is reabsorbed in renal proximal tubules (RPTs) by a protein called sodium-glucose cotransporter 2 (SGLT2). Since SGLT2 expression is upregulated and SGLT2-mediated glucose reabsorption is increased in the diabet...

Nutrition

What you eat has a direct effect on your kidneys, so your diet is a very important part of your treatment plan for chronic kidney disease.  Your dietary needs are unique to you, and they depend on a lot of factors, including your kidney function, your other medical conditions...

SUGARNSALT Project

The Sodium Glucose Co-Transport-2 Inhibition Diabetes and Kidney Function Loss in Type 1 Diabetes (SUGARNSALT) research project The Sodium Glucose Co-Transport-2 Inhibition Diabetes and Kidney Function Loss in Type 1 Diabetes (SUGARNSALT) is one of eight major research pro...

How Kidneys Work

Kidneys are a critical part of your health. They “clean” your blood by removing wastes from the body through your urine, help your body to make red blood cells, and regulate blood pressure. One of the main jobs of the kidneys is to remove wastes from the blood and return the c...

Molecular mechanisms mediating paracellular intestinal Pi absorption and the development of CVD

The most common cause of death in persons with kidney failure is cardiovascular disease. In persons with chronic kidney disease and end-stage renal disease, blood phosphate levels directly correlate with cardiovascular diseases including heart attack and stroke. This is becaus...

Your Diet On Dialysis

Most people who are on dialysis need to make some changes to the way they eat.  Choosing the right foods when you’re on dialysis is very important to your health and well-being, and it can sometimes be challenging.  There is no standard kidney diet; eating right on dialysis wi...

The role of prostaglandin E2 and their receptor subtypes on kidney disease

Lay Summary Hypertension and diabetes are leading causes of chronic kidney disease and both have reached epidemic status worldwide. Despite the many efforts aimed at understanding the pathogenesis of hypertensive kidney disease, to this day the therapeutic approaches are i...

The effects of SGLT2 inhibition on renal PGE2 mediated transport in diabetes

Lay Abstract We have worked with several diabetic models (8-10, 12) and have the materials and technical expertise to carry out the proposed biochemical, functional, and translational studies at the Kidney Research Centre. Considering the timeline needed to conduct these lo...

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