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GOaL Directed-STrategic Approach with New Disease-modifying theraApies to Reduce kidney and cardiova

Co-Applicant(s):  Andrew Pinto, Ann Young, Bourne Auguste, Christoph Wanner, Christopher Chan, Darrell Ginsberg, David Cherney, Husam Abdel-Qadir, Istvan Mucsi, Javed Butler, Lisa Dubrofsky, Michael Colacci, Nikolaus Marx, Peter Juni, Ron Wald, Ronald Pearlman, Samir Iskan ...

Kidney Community Kitchen

Diet plays a significant role in the management of chronic kidney disease to prevent the build-up of toxins that healthy kidneys normally remove and to reduce the workload of the kidneys. Proper food and fluid choices can contribute to delaying the need for dialysis treatment...

Nutrition in Chronic Kidney disease patients

Lay summary Do you eat bananas? Stop! Eat doughnuts instead. Sounds crazy doesn’t it? Well, if you are living with kidney disease, your health care provider may inadvertently be sending you this message. That is because people with kidney disease often need low potassium die...

Safety and efficacy of SGLT-2 inhibitors in patients with advanced CKD

Lay Abstract Sodium-glucose co-transporter-2 (SGLT-2) inhibitors were introduced in medical practice for the treatment of type 2 diabetes. Subsequently, they were found to protect against adverse cardiac events and progression of chronic kidney disease (CKD) to more advance...

Expanding the Use of SGLT-2 Inhibitors to Improve Cardiorenal Disease

Lay Abstract Background Sodium glucose co-transporter 2 (SGLT-2) inhibitors are a class of medication that alter blood flow in the kidney, thereby reducing the risks of developing heart failure and/ or kidney failure by up to 40%. These medications have been principally stu...

The efficacy, mechanisms and safety of SGLT2i and GLP1RA combination therapy in kidney transplant re

Lay Abstract Kidney transplant recipients (KTR) are at high risk of death from heart disease after transplantation, as well as graft failure, where the kidney transplant no longer works and dialysis or another kidney transplant is required.  New types of drugs called sodi...

Treatment Modalities for Kidney Failure

In the early stages of chronic kidney disease, lifestyle changes (such as getting more exercise, stopping smoking and cutting down on sodium), managing other medical conditions and taking a few medications may be all the treatment needed to slow the damage to the kidneys. Peo...

Deciphering the inflammatory proprieties of crystalloids: Why Saline is bad?

General Audience Summary Inflammation is present in all intensive care patients. Leukocytes, white blood cells are important in the inflammatory response. However, when the inflammation is too great, the compensatory mechanisms of the patients are overwhelmed and the pati...

The use of new glucose lowering therapies to reduce cardiorenal risk in kidney transplant recipients

Supervisor(s):  David Cherney Lay Abstract Background: Approximately 4 million Canadians live with chronic kidney disease, a progressive condition which worsens over time leading to kidney failure. Individuals with kidney failure suffer from disability, depression, incr...

Colleagues celebrate Dr. Chan’s Medal for Research Excellence

Elizabeth Myles, National Executive Director at The Kidney Foundation of Canada, and Dr. John Chan, Chief of the Laboratory of Molecular Endocrinology and Nephrology at the Research Centre of the Centre Hospitalier de l'Université de Montréal (CHUM) and Professor of Medicine...

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