Research Awards Recipients

Lay Abstract

The global incidence of chronic kidney disease (CKD) is on the rise mirroring the progressive increase of other chronic health complications, such as obesity, diabetes and hypertension. CKD occurs when the kidneys gradually stop functioning, ultimately resulting in kidney failure. While there are many causes of CKD, changes to the blood vessels of the kidney contribute substantially to the development and progression of kidney disease. In the current funding application, we propose to examine mouse models that mimic human CKD to understand how the blood vessel cells in the kidney change during the development and progression of CKD. By completing these experiments, we can further understand the role of the blood vessels in the development of CKD and identify new targets for treating CKD patients.