Marie-Luise Brezniceanu, PhD Supervisor: Dr. John Chan Award: KRESCENT Fellowship Institution: Hôtel Dieu – CHUM Year: 2006-2008 Dr. Marie-Luise Brezniceanu will complete her post-doctoral fellowship with Dr. John Chan at the Hôtel-Dieu Hospital (CHUM), where she will study hyperglycemia and activation of the Renin-Angiotensin System (RAS) in the initiation and progression of diabetic nephropathy. Forty percent of patients with End-Stage Renal Disease (ESRD) have an underlying diagnosis of diabetic nephropathy. Dr. Brezniceanu will study the molecular mechanisms of high glucose and intrarenal Reactive Oxygen Species (ROS) action in the hypertrophy and programmed cell death of proximal tubular cells in the kidney. An increase in our understanding of the role(s) of intrarenal ROS in the pathogenesis of diabetic nephropathy will directly contribute to improved clinical treatment. Previous Next